Tumor Dendritic Cells (DCs) Derived from Precursors of Conventional DCs Are Dispensable for Intratumor CTL Responses
نویسندگان
چکیده
منابع مشابه
Human dendritic cells (DCs) are derived from distinct circulating precursors that are precommitted to become CD1c+ or CD141+ DCs
In humans, conventional dendritic cells (cDCs) exist as two unique populations characterized by expression of CD1c and CD141. cDCs arise from increasingly restricted but well-defined bone marrow progenitors that include the common DC progenitor that differentiates into the pre-cDC, which is the direct precursor of cDCs. In this study, we show that pre-cDCs in humans are heterogeneous, consistin...
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Background: Leishmania is a pathogenic parasite which infects mononuclear cells in vertebrate hosts. Different strategies have been taken to develop immunity against Leishmania . DCs loaded with immunogenic antigen have resulted in different levels of Th1-type immune response and cytotoxic T lymphocytes (CTL) activity. Objective: To evaluate the potency of DCs primed with soluble Leishmania mex...
متن کاملCTL responses to DCs stimulated with leishmania antigens detected by DCs expressing Leishmania gp63.
BACKGROUND Leishmania is a pathogenic parasite which infects mononuclear cells in vertebrate hosts. Different strategies have been taken to develop immunity against Leishmania. DCs loaded with immunogenic antigen have resulted in different levels of Th1-type immune response and cytotoxic T lymphocytes (CTL) activity. OBJECTIVE To evaluate the potency of DCs primed with soluble Leishmania mexi...
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3 Timothy P. Moran1, 2, Keiko Nakano1, Gregory S. Whitehead1, Seddon Y. Thomas1, Donald 4 N. Cook1,3 and Hideki Nakano1,3 5 6 Immunity, Inflammation and Disease Laboratory, Division of Intramural Research, National 7 Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina 27709, 8 USA, Department of Pediatrics, University of North Carolina School of Medicine, Cha...
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ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2018
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.1701514